Author(s): Mollet, Inês G. ; Barbosa-Morais, Nuno ; Andrade, Jorge ; Carmo-Fonseca, Maria
Date: 2006
Persistent ID: http://hdl.handle.net/10451/47834
Origin: Repositório da Universidade de Lisboa
Project/scholarship: info:eu-repo/grantAgreement/FCT/POCI/POCTI%2FMGI%2F49430%2F2002/PT; info:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F2914%2F2000/PT;
Subject(s): CAPER; PUF60; RNA splicing; U2AF
© 2006 The Authors Journal compilation ©2006 FEBS
U2 snRNP auxiliary factor (U2AF) is an essential heterodimeric splicing factor composed of two subunits, U2AF(65) and U2AF(35). During the past few years, a number of proteins related to both U2AF(65) and U2AF(35) have been discovered. Here, we review the conserved structural features that characterize the U2AF protein families and their evolutionary emergence. We perform a comprehensive database search designed to identify U2AF protein isoforms produced by alternative splicing, and we discuss the potential implications of U2AF protein diversity for splicing regulation.
This work was supported by grants from Fundação para a Ciência e Tecnologia (FCT), Portugal (POCTI/MGI/49430/2002, SFRH/BD/2914/2000), the Muscular Dystrophy Association (MDA3662), and the European Commission (EURASNET, LSHG‐CT‐2005‐518238).
