Author(s): Gonçalves, Simone Queiroga Brito ; da Silva Filho, Eloi Alves ; de Oliveira, Osmair Vital ; Gonçalves, Arlan da Silva
Date: 2020
Origin: Oasisbr
Subject(s): Coronavirus; Protease; Molecular docking
Document details
CORONAVIRUS AND ITS MAIN PROTEASE: AN INSIGHT FOR DRUGS DESIGN BY MOLECULAR DOCKING
Description
Many viruses need their sulphydryl groups to be reduced in order to be allowed to enter cells. SARS-CoV-2, which belongs to Coronaviridae family and is responsible for coronavirus disease 2019 or COVID-19, has cysteine-rich proteins in its capsid as the main CoV protease (MPRO), which must be intact and active maintaining the viral activity. Considering that MPRO is an important molecular target for development of antiviral drugs, this work motivation was the structural study of the possible ways of interaction between drugs and viral cysteines by molecular docking technique for design of new potential inhibitors of MPRO and its virulence.
Document Type
Journal article
Language Portuguese
Language Portuguese
