Autor(es): Moraes, Clayton F. ; Souza, Elias R. ; Souza, Vinícius C. ; Medeiros, Eloá F.F ; Gonçalves, Thiago F. ; Tolêdo, Juliana O. ; Karnikowski, Mauro ; Gomes, Lucy ; Karnikowski, Margô Gomes de Oliveira ; Córdova, Cláudio Olavo de Almeida ; Nóbrega, Otávio de Tolêdo
Data: 2016
Identificador Persistente: http://hdl.handle.net/123456789/208
Origem: Oasisbr
Assunto(s): Renin angiotensin system; Polymorphism; Hypertension; Pharmacotherapy; Guidelines; Brazil
Made available in DSpace on 2016-10-10T03:51:31Z (GMT). No. of bitstreams: 5 A common polymorphism in the renin angiotensin system is associated with differential.pdf: 334227 bytes, checksum: 06c12daa2e863cfa07f1500998d20fbd (MD5) license_url: 52 bytes, checksum: 2f32edb9c19a57e928372a33fd08dba5 (MD5) license_text: 22213 bytes, checksum: a03e546c827bdf47d4a06cfce5c2fb1d (MD5) license_rdf: 23692 bytes, checksum: 13c15f5d379f2fc75f816604d123f74e (MD5) license.txt: 1818 bytes, checksum: 46de3043f08e87659ae535ef74b8ce9d (MD5) Previous issue date: 2008
Since variations on the renin angiotensin (RA) system tend to exert effects on blood pressure, we investigated the association of the common ACE and AT1R polymorphisms with response to a multivariate pharmacotherapy. Methods: This prospective study involved 169 hypertensive, community-dwelling older women. Genotypes were obtained by length analysis or direct sequencing of PCR products. Blood pressure-lowering pharmacotherapy was conducted according to current Brazilian Guidelines on Hypertension. Results: Genotype frequencies were in agreement to the Hardy–Weinberg equilibrium. Interventions were found to represent actual hypertension-management practices in Brazil, and accounted for a significant reduction in both systolic (Pb0.001) and diastolic (Pb0.001) blood pressure. Concerning the effect of polymorphisms, no influence of the ACE and AT1R genotypes were found on the magnitude of the treatmentinduced blood pressure reduction (PN0.05). Nonetheless, the clinical result varied according to the ACE alleles since mean systolic pressure was roughly 10 mm Hg higher in insertion (I) homozygotes than in the deletion (D) counterparts either in baseline (P=0.001) and endpoint (P=0.010). Conclusion: The outcome of the antihypertensive pharmacotherapy advocated by national guidelines was significantly influenced by the ACE I/D polymorphism but not by the AT1R 1166 A/C polymorphism among postmenopausal women.
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