A3.6 Two components contributing to reduced treg surface CD25 in sle patients and their unaffected relatives

• Author(s): Costa, N ; Marques, O ; Godinho, S ; Carvalho, C ; Leal, B ; Vasconcelos, C ; Marinho, A ; Moraes-Fontes, M F ; Gomes da Costa, A ; Ponte, C ; Marques, R ; Coias, T ; Martins, A R ; Viana, J F ; Martins, B ; Fesel, C
• Date: 2014
• Persistent ID: http://hdl.handle.net/10400.7/677
• Origin: ARCA - Access to Research and Communication Annals
• Subject(s): Systemic Lupus Erythematosus (SLE); CD25; FOXP3+
• Document Type: Journal article
• Language: English
• Contributor(s): ARCA

Description

Background FOXP3+ regulatory T-cells (Tregs) in Systemic Lupus Erythematosus (SLE) are in a functionally deficient state with a characteristic reduction or absence of surface CD25 (the IL-2 receptor alpha chain). Genetic variation in the CD25-encoding IL2RA locus is associated with other autoimmune disorders.