Author(s): Soares, Miguel P ; Gozzelino, Raffaella ; Weis, Sebastian
Date: 2014
Persistent ID: http://hdl.handle.net/10400.7/771
Origin: ARCA - Access to Research and Communication Annals
Subject(s): tissue damage control; disease tolerance; stress response; damage response; infection
Immune-driven resistance mechanisms are the prevailing host defense strategy against infection. By contrast, disease tolerance mechanisms limit disease severity by preventing tissue damage or ameliorating tissue function without interfering with pathogen load. We propose here that tissue damage control underlies many of the protective effects of disease tolerance. We explore the mechanisms of cellular adaptation that underlie tissue damage control in response to infection as well as sterile inflammation, integrating both stress and damage responses. Finally, we discuss the potential impact of targeting these mechanisms in the treatment of disease.
