Author(s): Bergman, Marie-Louise ; Lopes-Carvalho, Thiago ; Martins, Ana-Catarina ; Grieco, Fabio A. ; Eizirik, Décio L. ; Demengeot, Jocelyne
Date: 2017
Persistent ID: http://hdl.handle.net/10400.7/819
Origin: ARCA - Access to Research and Communication Annals
Project/scholarship: info:eu-repo/grantAgreement/EC/FP7/241447/EU;
Subject(s): Autoimmunity; diabetes; insulin; Vaccination
This deposit is composed by the main article plus the supplementary materials of the publication.
Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.
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