Autor(es): Nascimento, Dahan da Cunha
Data: 2018
Origem: Oasisbr
Assunto(s): Idosos; Obesidade; Inflama????o; Contra????es exc??ntricas; Marcadores sangu??neos; Matriz metaloproteinase; Matrix metalloproteinases; Eccentric contraction; Blood markers; Inflammation; Obesity; Elderly; CNPQ::CIENCIAS DA SAUDE::EDUCACAO FISICA
Submitted by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-08-08T14:26:09Z No. of bitstreams: 1 DahandaCunhaNascimentoDissertacao2015.pdf: 2333475 bytes, checksum: e3be1599bee31093a1f4cfdee83483dc (MD5)
Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-08-08T14:26:16Z (GMT) No. of bitstreams: 1 DahandaCunhaNascimentoDissertacao2015.pdf: 2333475 bytes, checksum: e3be1599bee31093a1f4cfdee83483dc (MD5)
Made available in DSpace on 2018-08-08T14:26:16Z (GMT). No. of bitstreams: 1 DahandaCunhaNascimentoDissertacao2015.pdf: 2333475 bytes, checksum: e3be1599bee31093a1f4cfdee83483dc (MD5) Previous issue date: 2015-03-04
Matrix metalloproteinases (MMPs) belong to a group of endopeptidases which regulate the composition of the extracellular matrix (ECM) and its imbalance contributes to the development of many pathological conditions. Among them, obesity. Aging is associated with several degenerative processes and physiological changes. Body fat increment in elderly women is also responsible for increased systemic concentrations of matrix metalloproteinases 2 and -9 and also by the upregulation of proinflammatory cytokines. In another hand, studies that analyzed the effects of physical exercise on MMPs concentrations. Aerobic training was effective in decreasing plasma concentrations of MMP-2 and MMP-9 in obese, type 2 diabetes mellitus, metabolic syndrome and elderly with cardiovascular disease, indicating transient cardioprotective effect. However, strength training also shows conflicting results. Considering its importance in aging, especially eccentric training method and its effects on functional capacity when compared to the traditional method, there is evidence that this type of resistance training method is able to decrease the activity of MMPs 48 hours after an acute exercise session of eccentric training in elderly obese women, indicating a transitory cardioprotective effect. However, there are still many challenges to a better understanding of its importance on muscle adaptation or indicative of a pro-inflammatory profile on obesity. Therefore, more studies should be conducted and measures such as muscle biopsy should also be included because they might explain the process of muscle adaptation to exercise.
As metaloproteinases da matriz extracelular (MMPs) pertencem a um grupo de enzimas endopeptidases que regulam a composi????o da matriz extracelular (MEC) e seu desequil??brio contribui para o desenvolvimento de muitas condi????es patol??gicas, dentre elas, a obesidade. Como o envelhecimento est?? associado a v??rios processos degenerativos e mudan??as fisiol??gicas, o aumento da gordura corporal em mulheres idosas ?? tamb??m respons??vel pelo aumento das concentra????es sist??micas das metaloproteinases da matriz extracelular tipo 2 e 9 (MMPs) e tamb??m pelo desequil??brio nas concentra????es de citocinas pr??-inflamat??rias. Apesar dessas modifica????es, estudos sobre o efeito do exerc??cio f??sico, especificamente o treinamento aer??bio demonstraram sua efetividade na diminui????o das concentra????es plasm??ticas das MMP-2 e MMP-9 em indiv??duos obesos, diabetes mellitus tipo 2, s??ndrome metab??lica e idosos com problemas card??acos, indicando um efeito cardioprotetor. No entanto, o treinamento de for??a ainda demonstra resultados conflitantes. Considerando a sua import??ncia no envelhecimento, principalmente o treinamento exc??ntrico, al??m de seus benef??cios sobre a capacidade funcional j?? reportados na literatura quando comparado ao m??todo tradicional, h?? ind??cios na literatura de que esse tipo de m??todo ?? capaz de diminuir a atividade das MMPs 48 horas ap??s uma sess??o aguda em mulheres idosas obesas, indicando um efeito cardioprotetor transit??rio. No entanto, ainda existem muitos desafios para o melhor entendimento de sua import??ncia na adapta????o muscular ou indicativo de um estado inflamat??rio caracter??stico na obesidade. Por isso, mais estudos devem ser conduzidos e outras medidas como bi??psia muscular tamb??m devem ser inclu??das, pois as mesmas podem explicar o processo de adapta????o ao exerc??cio f??sico.
