Author(s): Franco, Joana ; Cavaleiro, Inês ; Bernardes, Catarina ; Ribeiro, Ana Clara ; Silva, Alexandra Maia e
Date: 2015
Persistent ID: http://hdl.handle.net/10400.26/14758
Origin: Egas Moniz - Cooperativa de Ensino Superior, CRL
Subject(s): rs266882; KLK3 gene; RFLPPCR; Prostate cancer
"The prostate cancer (PC) is one of the most frequent neoplasia in men even though not the deadliest. Every year more than 1,1 million men are diagnose with PC worldwide. The principal risks factors are: age, diet, familiar predisposition, race and hormones. Gleason classification is use to graduate PC based upon the histologic pattern of tumoral growth. Additionally to this classification is use TNM that allow to describe the cancer severity for each individual. Prostate-specific antigen (PSA) has been used as biomarker of PC, however it isn´t a specific marker for cancer detection. This protein is coded by KLK3 gene (located at 19q13.41) and it is regulated by androgen receptors through ligation to consensus sequences in promoter region of KLK3 – Androgen Response Elements (ARE). In ARE-I, located at -158 position, there is a single polymorphism nucleotide (SNP) named rs266882, which consists of substitution of guanine (G) for adenine (A)."
