A variante genética c825t da subunidade β3 da proteína G associa‐se com a hipertensão arterial numa população portuguesa

• Author(s): Sousa, Ana Célia ; Palma dos Reis, Roberto ; Pereira, Andreia ; Borges, Sofia ; Gouveia, Sara ; Spínola, Adelaide ; Freitas, Ana Isabel ; Guerra, Graça ; Góis, Teresa ; Rodrigues, Mariana ; Henriques, Eva ; Ornelas, Ilídio ; Freitas, Carolina ; Pereira, Décio ; Brehm, António ; Mendonça, Maria Isabel
• Date: 2018
• Persistent ID: http://hdl.handle.net/10400.26/27893
• Origin: Serviço de Saúde da Região Autónoma da Madeira, E.P.E.
• Subject(s): Case-Control Studies; Heterotrimeric GTP-Binding Proteins; Hypertension; Portugal; Genetic Variation; Polymorphism, Genetic; Estudo caso‐controlo; Hipertensão arterial; Proteína G; Polimorfismos; GNβ3; G protein; Madeira Island; Portugal
• Document Type: Journal article
• Language: Portuguese
• Contributor(s): Repositório Comum

Description

Hypertension is an important public health problem, affecting about 25% of the adult population worldwide.1 Genetic and environmental factors contribute to its pathogenesis. The T allele of the C825T polymorphism of the beta 3 subunit of G protein (rs5443) leads to the production of a truncated variant that enhances intracellular signaling and may interfere with the regulation of blood pressure. This genetic variant has been described as a risk factor for hypertension, although study results are controversial.