Autor(es): Grunho, Miguel ; Godinho, Catarina ; Patita, Marta ; Mocanu, Irina ; Vieira, Ana Isabel ; De Matos, António ; Carregosa, Ricardo ; Marx, Frederico ; Tomé, Morgane ; Sousa-Catita, Diogo ; Proença, Luís ; Outeiro, Tiago ; Fonseca, Jorge
Data: 2021
Identificador Persistente: http://hdl.handle.net/10400.26/40113
Origem: Egas Moniz - Cooperativa de Ensino Superior, CRL
Assunto(s): inflammatory bowel disease; Parkinson’s disease; gut alpha-synuclein aggregates
The hallmark of Parkinson’s disease (PD) is the accumulation of alpha-synuclein (AS) aggregates. Prior to the central nervous system involvement, PD establishes itself in the gut as a result of the complex interplay between microbiota, the host’s immune/neural systems and increased intestinal permeability. Inflammatory Bowel Disease (IBD) patients present a higher number of AS aggregates in the intestinal wall and an increased risk of developing PD. By studying AS aggregates in gut biopsy specimens of IBD patients and controls, this project aims to further clarify the pathophysiology of PD and to explore the potential of gut a biopsy for AS aggregates as a biomarker for prodromal PD.
