Performance and paroxetine stability in tablets manufactured by fused deposition modelling-based 3D printing

• Autor(es): Figueiredo, Sara ; Fernandes, A.I. ; Carvalho, Fátima G. ; Pinto, João F.
• Data: 2022
• Identificador Persistente: http://hdl.handle.net/10400.26/41804
• Origem: Egas Moniz - Cooperativa de Ensino Superior, CRL
• Assunto(s): 3D-printed tablet; Filament; Hot-melt extrusion (HME); Paroxetine; Individualized medicines
• Tipo de Documento: Artigo científico
• Idioma: Inglês
• Contribuidor(es): Repositório Comum

Descrição

Objectives: The objective of this study was to develop a method for the preparation and characterization of paroxetine (PRX) tablets, obtained by coupling hot-melt extrusion and fused deposition modelling (FDM)-based three-dimensional printing (3DP) technology. The impact of the printing process parameters on the drug stability and on the tablets performance was assessed.