Performance and paroxetine stability in tablets manufactured by fused deposition modelling-based 3D printing

• Author(s): Figueiredo, Sara ; Fernandes, Ana I. ; Carvalho, Fátima G. ; Pinto, João F.
• Date: 2022
• Persistent ID: http://hdl.handle.net/10400.26/44367
• Origin: Egas Moniz - Cooperativa de Ensino Superior, CRL
• Subject(s): 3D-printed tablet; Filament; Fused deposition modelling (FDM); Hot-melt extrusion (HME); Paroxetine; Individualized medicines
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório Comum

Description

"Objectives: The objective of this study was to develop a method for the preparation and characterization of paroxetine (PRX) tablets, obtained by coupling hot-melt extrusion and fused deposition modelling (FDM)-based three-dimensional printing (3DP) technology. The impact of the printing process parameters on the drug stability and on the tablets performance was assessed.