Author(s): Rosinha, A ; Rabaça, C ; Calais, F ; Pinto, JM ; Barreira, JV ; Fernandes, R ; Ramos, R ; Fialho, AC ; Palma dos Reis, J
Date: 2024
Persistent ID: http://hdl.handle.net/10400.26/49844
Origin: Saúde - CUF
Subject(s): Neoplasias de Próstata Resistentes à Castração; Prostatic Neoplasms, Castration-Resistant
Non-metastatic castration-resistant prostate cancer (nmCRPC) represents a challenging disease state in prostate cancer care. nmCRPC patients with a high risk of progression to metastatic disease who are identified by a prostate-specific antigen doubling time (PSADT) ≤10 months are eligible for treatment with the novel androgen receptor inhibitors (ARIs), shown to delay disease progression and extend survival. However, nmCRPC is often unexploited in clinical practice due to a lack of standardization in the methodology and in the tools used for its identification. In this article, a group of Urology and Oncology specialists with acknowledged expertise in prostate cancer reviews the state of the art in the management of high-risk nmCRPC patients, identifies gaps and unmet needs, and proposes strategies to optimize the identification of this patient subgroup in the clinical practice and improve their health outcomes.
