Autor(es): Canales, Giancarlo De la Torre ; Poluha, Rodrigo Lorenzi ; Pinzón, Natalia Alvarez ; Silva, Bruno Rodrigues Da ; Almeida, André Mariz ; Ernberg, Malin ; Manso, Ana Cristina ; Bonjardim, Leonardo Rigoldi ; Rizzatti-Barbosa, Célia Marisa
Data: 2022
Identificador Persistente: http://hdl.handle.net/10400.26/59553
Origem: Egas Moniz - Cooperativa de Ensino Superior, CRL
Assunto(s): botulinum toxin type A; myofascial pain; temporomandibular disorders
This study assessed the effects of botulinum toxin type A (BoNT-A) in mandibular range of motion and muscle tenderness to palpation in persistent myofascial pain (MFP) patients (ReBEC RBR-2d4vvv). Eighty consecutive female subjects with persistent MFP, were randomly divided into four groups (n = 20): three BoNT-A groups with different doses and a saline solution group (placebo control group). Treatments were injected bilaterally in the masseter and anterior temporalis muscle in a single session. Clinical measurements of mandibular movements included: pain-free opening, maximum unassisted and assisted opening, and right and left lateral excursions. Palpation tests were performed bilaterally in the masseter and temporalis muscle. Follow-up occurred 28 and 180 days after treatment. For the statistical analysis the Mann–Whitney U-test with Bonferroni correction was used for groups comparisons. Regardless of dose, all parameters of mandibular range of motion significantly improved after 180 days in all BoNT-A groups, compared with the control group. Palpation pain over the masseter and temporalis muscles were significantly reduced in all BoNT-A groups regardless of dose, compared with the control group, after 28 and 180 days of treatment. Independent of doses, BoNT-A improved mandibular range of motion and muscle tenderness to palpation in persistent MFP patients.
