Author(s): Nunes, Raquel J. ; Oliveira, Paula de ; Lages, Ana ; Becker, Jörg D. ; Marcelino, Paulo ; Barroso, Eduardo ; Perdigoto, Rui ; Kelly, Jeffery W. ; Quintas, Alexandre ; Santos, Susana C. R.
Date: 2013
Persistent ID: http://hdl.handle.net/10400.26/6945
Origin: Egas Moniz - Cooperativa de Ensino Superior, CRL
Subject(s): Angiogenesis; Endothelial Cell; Familial Amyloidotic Polyneuropathy; Gene Expression; Microarray; Transthyretin; Vascular Biology
"Background: The biological effects of transthyretin proteins on vasculature remain unknown. Results: V30M transthyretin tetramer modulates endothelial global gene expression, down-regulating pro-angiogenic genes, inducing apoptosis and inhibiting migration. Conclusion: Transthyretin proteins regulate angiogenesis by conferring different molecular identities to endothelial cells. Significance: This work has critical implications in the prevention of early hepatic artery thrombosis in familial amyloidotic polyneuropathy patients after liver transplantation."
