Author(s): Wang, Zhao ; Olim, Filipe ; Sun, Jingjing ; Neves, Ana Rute ; Mendes, Fátima ; Tomás, Helena ; Sheng, Ruilong
Date: 2021
Persistent ID: http://hdl.handle.net/10400.13/3821
Origin: DigitUMa - Repositório da Universidade da Madeira
Subject(s): Polymers; Doxorubicin; Prodrug; Stimuli-responsive; Drug delivery; Nanosystem; .; Faculdade de Ciências Exatas e da Engenharia; Centro de Química da Madeira
Utilizing biocompatible polymers as platforms to covalently conjugate with chemotherapeutics to construct polymer-based prodrugs and their nano drug delivery systems has attracted great attention in recent years. This perspective reviewed state-of-the-arts for polymer-based doxorubicin prodrugs and the related nanodelivery systems, including: (1) pH-responsive polymer-doxorubicin prodrugs/conjugates; (2) pH/redox dual responsive prodrugs/conjugates; (3) reactive oxygen species/hypoxia-responsive polymer-doxorubicin prodrugs; (4) tumor receptor targeting polymer prodrugs; (5) enzyme-responsive polymer-doxorubicin prodrugs. Finally, possible future perspectives were also stated and discussed.
