Autor(es):
Souto, Eliana B. ; Campos, Joana R. ; Ana, Raquel da ; Fangueiro, Joana F. ; Martins-Gomes, Carlos ; Durazzo, Alessandra ; Lucarini, Massimo ; Sánchez López, Elena ; Espina, Marta ; García, Maria Luisa ; Silva, Amélia M. ; Mendonça, Fernando ; Santini, Antonello ; Souto, Selma B.
Data: 2020
Identificador Persistente: https://hdl.handle.net/10316/105799
Origem: Estudo Geral - Universidade de Coimbra
Assunto(s): angiogenesis; vascular endothelial growth factor; inflammation; diabetic retinopathy; uveal melanoma; anti-angiogenic therapy
Descrição
Diabetic retinopathy causes vascular damage to retinal neurons, presenting characteristics of chronic inflammation. The development of new therapies capable of combating vision loss involves knowledge of inflammatory retinal changes. Studies in animal models and patients with diabetes have shown a high expression of the inflammatory molecules that are involved in the progression of diabetic retinopathy. Uveal melanoma is an eye tumour that remains highly deadly, because despite the correct treatment, it still causes metastasis in about 50% of patients. This type of tumour has the ability to produce and store melanin, which may result in resistance to therapy. Over time there has been development of new therapies for this disease, such as radiotherapy and surgical resection. In this review, we discuss diabetic retinopathy and ocular melanoma, their relationship with angiogenesis and the current anti-angiogenic therapies for their treatment.
Research project: Nutraceutica come supporto nutrizionale nel paziente oncologico, CUP: B83D18000140007 and M-ERA-NET/0004/2015-PAIRED.
