Germline Genetic Variants of the Renin-Angiotensin System, Hypoxia and Angiogenesis in Non-Small Cell Lung Cancer Progression: Discovery and Validation Studies

• Author(s): Catarata, Maria Joana ; Medeiros, Rui ; Oliveira, Maria José ; Pêgo, Alice ; Frade, João Gonçalo ; Martins, Maria de Fátima ; Cordeiro, Carlos Robalo ; Herth, Felix J. F. ; Thomas, Michael ; Kriegsmann, Mark ; Meister, Michael ; Schneider, Marc A ; Muley, Thomas ; Ribeiro, Ricardo
• Date: 2020
• Persistent ID: https://hdl.handle.net/10316/105854
• Origin: Estudo Geral - Universidade de Coimbra
• Subject(s): genetic polymorphisms; lung cancer; renin–angiotensin; hypoxia; angiogenesis
• Document Type: Journal article
• Language: English

Description

The renin-angiotensin system (RAS) is involved in cell proliferation, immunoinflammatory response, hypoxia and angiogenesis, which are critical biological processes in lung cancer. Our aim was to study the association of putatively functional genetic polymorphisms in genes coding for proteins involved in RAS, hypoxia and angiogenesis with non-small cell lung cancer (NSCLC) prognosis.