Autor(es):
Leston, Sara ; Freitas, Andreia ; Rosa, João ; Vila Pouca, Ana Sofia ; Barbosa, Jorge ; Reis-Santos, Patrick ; Fonseca, Vanessa F. ; Pardal, Miguel ; Ramos, Fernando
Data: 2023
Identificador Persistente: https://hdl.handle.net/10316/113276
Origem: Estudo Geral - Universidade de Coimbra
Projeto/bolsa:
info:eu-repo/grantAgreement/other/04292/2020/other;
info:eu-repo/grantAgreement/other/04292//other;
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/PT;
Assunto(s): environmental contamination; emerging contaminants; drugs; seawater; UHPLC-TOF-MS
Descrição
Anthropogenic chemical contamination represents a key stressor of natural environments with pharmaceuticals comprising a particular group of emerging pollutants with the potential to induce biological responses in non-target organisms. Therefore, an analytical method based on ultra-high-performance liquid chromatography coupled to time-of-flight tandem mass spectrometry (UHPLC-TOF-MS) was developed for estuarine and seawaters, targeting 63 globally used pharmaceuticals (including amoxicillin, ciprofloxacin, sulfamethoxazole, trimethoprim and venlafaxine included in the SurfaceWaterWatch List) from 8 therapeutic groups: antibiotics, analgesic, NSAIDs, antidepressants, -blockers, lipid regulators, anticonvulsants and antihypertensive drugs. The method presents high selectivity and sensitivity, with the limits of detection ranging from 0.01 to 8.92 ng/L and the limits of quantification from 0.02 to 29.73 ng/L. Considering precision, the highest value was achieved for amoxicillin (20.9%) and the lower for ofloxacin (2.6%), while recoveries ranged from 80.6 to 112.6%. Overall, the quantification method was highly efficient for multi-residues quantification in such complex environmental samples.
