Author(s):
Whiteside, David J. ; Malpetti, Maura ; Jones, P Simon ; Ghosh, Boyd C. P. ; Coyle-Gilchrist, Ian ; van Swieten, John C. ; Seelaar, Harro ; Jiskoot, Lize ; Borroni, Barbara ; Sánchez-Valle, Raquel ; Moreno, Fermin ; Laforce, Robert ; Graff, Caroline ; Synofzik, Matthis ; Galimberti, Daniela ; Masellis, Mario ; Tartaglia, Maria Carmela ; Finger, Elizabeth ; Vandenberghe, Rik ; de Mendonça, Alexandre ; Tagliavini, Fabrizio ; Butler, Chris R. ; Santana, Isabel ; Ber, Isabelle Le ; Gerhard, Alexander ; Ducharme, Simon ; Levin, Johannes ; Danek, Adrian ; Otto, Markus ; Sorbi, Sandro ; Pasquier, Florence ; Bouzigues, Arabella ; Russell, Lucy L. ; Rohrer, Jonathan D. ; Rowe, James B. ; Rittman, Timothy
Date: 2023
Persistent ID: https://hdl.handle.net/10316/113589
Origin: Estudo Geral - Universidade de Coimbra
Subject(s): disease progression; frontotemporal dementia; functional magnetic resonance imaging (fMRI); network dynamics; presymptomatic; Humans; Mutation; Brain; Magnetic Resonance Imaging; Frontotemporal Dementia; Cognitive Dysfunction
Description
Introduction: We tested whether changes in functional networks predict cognitive decline and conversion from the presymptomatic prodrome to symptomatic disease in familial frontotemporal dementia (FTD). Methods: For hypothesis generation, 36 participants with behavioral variant FTD (bvFTD) and 34 controls were recruited from one site. For hypothesis testing, we studied 198 symptomatic FTD mutation carriers, 341 presymptomatic mutation carriers, and 329 family members without mutations. We compared functional network dynamics between groups, with clinical severity and with longitudinal clinical progression. Results: We identified a characteristic pattern of dynamic network changes in FTD, which correlated with neuropsychological impairment. Among presymptomatic mutation carriers, this pattern of network dynamics was found to a greater extent in those who subsequently converted to the symptomatic phase. Baseline network dynamic changes predicted future cognitive decline in symptomatic participants and older presymptomatic participants. Discussion: Dynamic network abnormalities in FTD predict cognitive decline and symptomatic conversion.
