Autor(es):
Trettel, Caio Dos Santos ; Pelozin, Bruno Rocha de Avila ; Barros, Marcelo Paes ; Bachi, André Luis Lacerda ; Braga, Pedro Gabriel Senger ; Momesso, César Miguel ; Furtado, Guilherme Eustáquio ; Valente, Pedro Afonso ; Oliveira, Edilamar Menezes ; Hogervorst, Eef ; Fernandes, Tiago A.
Data: 2023
Identificador Persistente: https://hdl.handle.net/10316/113939
Origem: Estudo Geral - Universidade de Coimbra
Assunto(s): skeletal muscle; exercise; exerkines; myokines; oxidative stress; inflammaging; Humans; Quality of Life; Anti-Inflammatory Agents; Aging; Oxidation-Reduction; Fibronectins; Muscle, Skeletal
Descrição
Human beings lead largely sedentary lives. From an evolutionary perspective, such lifestyle is not beneficial to health. Exercise can promote many enabling pathways, particularly through circulating exerkines, to optimize individual health and quality of life. Such benefits might explain the protective effects of exercise against aging and noncommunicable diseases. Nevertheless, the miRNA-mediated molecular mechanisms and exerkine interorgan crosstalk that underlie the beneficial effects of exercise remain poorly understood. In this mini review, we focused on the exerkine, irisin, mainly produced by muscle contraction during adaptation to exercise and its beneficial effects on body homeostasis. Herein, the complex role of irisin in metabolism and inflammation is described, including its subsequent effects on thermogenesis through browning to control obesity and improve glycemic regulation for diabetes mellitus control, its potential to improve cognitive function (via brain derived neurotrophic factor), and its pathways of action and role in aging.
Coordenação de Aperfeiçoamento de Pessoal de Nı́vel Superior (CAPES) through the “Programa de Suporte a Pós-Graduação de Instituições de Ensino Particulares (PROSUP) and CAPES-PROEX” (grant number: 0001 and #88887.484856/2020-00), Brazil; the São Paulo Research Foundation (FAPESP: #2015/17275-8, #2017/06032-2, and #2022/03138-2); and the National Council for Scientific and Technological Development (CNPq: #409629/2021-9, #311839/2021-5, and #313376/2021-2). The authors would also like to thank the National funding by FCT- Foundation for Science and Technology, P.I., through the institutional scientific employment program-contract (CEECINST/00077/2021).
