Autor(es): Novo, João P. ; Gee, Lucy ; Caetano, Carolina A ; Tomé, Inês ; Vilaça, Andreia ; von Zglinicki, Thomas ; Moreira, Irina S ; Jurk, Diana ; Rosa, Susana ; Ferreira, Lino
Data: 2024
Identificador Persistente: https://hdl.handle.net/10316/116668
Origem: Estudo Geral - Universidade de Coimbra
Assunto(s): aging; blood–brain barrier; brain endothelial cells; senescence; senolytics
BBB dysfunction during aging is characterized by an increase in its permeability and phenotypic alterations of brain endothelial cells (BECs) including dysregulation of tight junction's expression. Here we have investigated the role of BEC senescence in the dysfunction of the BBB. Our results suggest that the transition from young to aged BBB is mediated, at least in part by BEC senescence.
SR acknowledges the funding by COMPETE2020 and FCT pro-grams [PTDC/BTM-SAL/5174/2020 entitled “A therapeutic strat-egy to fight blood-brain-barrier (BBB) ageing”] and DL 57/2016/CP1448/CT0018. LF acknowledges the funding of COMPETE2020and FCT programs [2022.07615.PTDC] as well as EC funding(“RESETageing” project-Ref: 952266 and “CHAngeing” project-Ref:101087071), (Excellence Hubs- HORIZON-WIDERA-2022-ACCESS-04- 01) project. DJ was funded by NIA R01 AG068182- 01 and NIAR01 AG062413- 02S1. TZ acknowledges funding by BBSRC BB/S006710/1.
