Author(s): Jimenez, Laísa Simakawa, 1990- ; Pareja, José Carlos, 1940- ; Chaim, Elinton Adami, 1957- ; Cazzo, Everton, 1979-
Date: 2020
Persistent ID: https://hdl.handle.net/20.500.12733/1643427
Origin: Oasisbr
Subject(s): Cirurgia bariátrica; Taxa de filtração glomerular; Nefropatias; Obesidade; Kidney diseases; Obesity; Bariatric surgery; Glomerular filtration rate; Gastric bypass; Artigo original
Abstract: While evidence of improved renal function following gastric bypass exists, pre-operative predictors of this improvement are not completely known.To assess the glomerular filtration rate (GFR) 1 year after Roux-en-Y gastric bypass (RYGB) and to identify pre-operative predictors associated with the improvement of renal function.A historical cohort study, which included 109 obese patients before and 12 months after RYGB, was classified into subgroups according to GFR (normofiltration, hypofiltration (GFR < 5th percentile), and hyperfiltration (GFR > 95th percentile)). The 5th and 95th percentiles were 90 and 120 mL/min/1.73 m2, respectively. The primary outcome was the variation of GFR (%GFR) estimated by the Chronic Kidney Disease - Epidemiology Collaboration (CKD-EPI) formula, calculated using serum creatinine, ethnicity, and gender. The mean age was 38.3 ± 10.3 years and 77% were female; 52.3% presented hypertension and 27.5% type 2 diabetes. One year after surgery, the mean BMI decreased from 36.7 ± 3.6 to 28.8 ± 3.3 kg/m2 (p < 0.001). Pre-surgically, 37.6% presented hypofiltration, 47.7% normofiltration, and 14.7% hyperfiltration. The overall GFR increased from 95.5 ± 19 to 104 ± 16.4 mL/min (10.9%) (p < 0.001). The overall post-surgical %GFR was negatively correlated with the pre-surgical GFR (R = -0.687; p < 0.001). In the hypofiltration and normofiltration subgroups, the post-surgical %GFR was negatively correlated with age (R = -0.328, p = 0.036; and R = -0.355, p = 0.004, respectively) and pre-surgical GFR (R = -0.436, p = 0.04; and R = -0.528, p < 0.001, respectively)
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