Autor(es): Lima, Ellen Nogueira, 1992- ; Lamas, Celina de Almeida, 1990- ; Baseggio, Andressa Mara, 1991- ; Vale, Jéssica Stephany Fernandes do, 1990- ; Maróstica Junior, Mário Roberto, 1980- ; Cagnon, Valéria Helena Alves, 1967-
Data: 2019
Identificador Persistente: https://hdl.handle.net/20.500.12733/1661407
Origem: Oasisbr
Assunto(s): Sobrepeso; Neoplasias da próstata; Obesidade; Prostatic neoplasms; Overweight; Obesity; Clinical studies; Artigo original; Jabuticaba
Agradecimentos: This study was financed in part by the Coordination for the Qualification of Higher Level Staff in Brazil (Brazil) - Finance Code 001 and FAPESP (São Paulo Research Foundation-2018/04579-7)
Abstract: Prostate cancer (PCa), overweight and obesity are frequent worldwide health problems. Clinical studies have shown that increased high-fat diet (HFD) consumption is associated with higher incidence of PCa. Brazilian berries, such as Myrciaria jaboticaba (Vell.) Berg, present high polyphenol concentration in the peel and exhibit positive effects on metabolic disorders and hepatic lesions. Therefore, the aim of the study herein was to investigate the patented jaboticaba peel extract effects (PJE) on different metabolic parameters and liver histopathology in the transgenic adenocarcinoma of the mouse prostate model, receiving a either normolipid diet or HFD for 8 weeks. The results showed that PJE reduced insulin resistance and glucose intolerance, decreased hepatic lipid accumulation, and inflammatory markers such as PPARgama and TNFalpha, respectively. In conclusion, the PJE treatment promoted protective effects in the metabolism of insulin and glucose and liver imbalance caused by HFD intake in the PCa model, suggesting that it may be a good protector against metabolic disorders present in overweight and associated with PCa
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
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