Author(s):
Camacho, Mariana Ramos Fernandes, 1986- ; Etchebehere, Elba Cristina Sa de Camargo, 1967- ; Tardelli, Natália Rocha ; Delamain, Marcia Torresan, 1971- ; Verçosa, Alinne Fernanda Amaral, 1982- ; Takahashi, Maria Emilia Seren, 1985- ; Brunetto, Sérgio Querino, 1955- ; Lorand-Metze, Irene, 1945- ; Souza, Carmino Antonio de, 1951- ; Ramos, Celso Darío, 1964-
Date: 2020
Persistent ID: https://hdl.handle.net/20.500.12733/1770
Origin: Oasisbr
Subject(s): Doença de Hodgkin; Tomografia computadorizada com tomografia por emissão de pósitrons; Glicólise; Hodgkin disease; Positron emission tomography computed tomography; Glycolysis; Metabolic tumor volume; Total lesion glycolysis; Fluordeoxiglicose; Volume of interest; Standard uptake value; Artigo original
Description
Agradecimentos: The Nuclear and Energy Research Institute (IPEN-CNEN), Sao Paulo, Brazil, kindly supplied the radiopharmaceuticals used in the present project (IPEN/UNICAMP agreement 01342000458/2017-15). Financial support was provided by FAPESP (Fundacao de Amparo a Pesquisa do Estado de Sao Paulo, grants 2009/54065-0 and 2018/00654-4). Celso Ramos has a research grant from CNPq (National Council of Research, proc 311841/2018-0). Irene Metze has a research grant from CNPq (National Council of Research, proc 305110/2018-7). No other potential conflict of interest relevant to this article was reported
Abstract: Quantification of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) can be time-consuming. We evaluated the performance of an automatic multifocal segmentation (MFS) method of quantification in patients with different stages of Hodgkin lymphoma, using the multiple VOI (MV) method as reference. Methods: This prospective bicentric study included 50 patients with Hodgkin lymphoma who underwent staging F-18-FGD PET/CT. The examinations were centrally reviewed and processed with commercial MFS software to obtain MTV and TLG using 2 fixed relative thresholds (40% and 20% of SUV max ) for each lesion. All PET/CT scans were processed using the MV and MFS methods. Interclass correlation coefficients and Bland-Altman plots were used for statistical analysis. Repeated calculations of MW and TLG values by 2 observers with different degrees of PET/CT imaging experience were used to ascertain interobserver agreement on the MFS method. Results: The means and SDs obtained for the MW with MV and MFS were, respectively, 736 +/- 856 mL and 660 +/- 699 mL for the 20% threshold and 313 +/- 359 mL and 372 +/- 434 mL for the 40% threshold. The time spent calculating the MW was much shorter with the MFS method than with the MV method (median time, 11.6 min [range, 1-30 min] and 64.4 min [range, 1-240 min], respectively), especially in patients with advanced disease. Time spent was similar in patients with localized disease. There were no statistical differences between the MFS values obtained by the 2 different observers. Conclusion: MTV and TLG calculations using MFS are reproducible, generate similar results to those obtained with MV, and are much less timing-consuming. Main differences between the 2 methods were related to difficulties in avoiding overlay of VOIs in the MV technique. MV and MFS perform equally well in patients with a small number of lesions
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ
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