Author(s): Correa, Rodrigo de Souza ; Oliveira, Katia Mara de ; Pérez, Hiram ; Stevens, Ana María Plutín ; Cairo, Raúl Ramos ; Mocelo, Raúl ; Castellano, Eduardo Ernesto ; Batista, Alzir Azevedo
Date: 2020
Origin: Oasisbr
Subject(s): Platinum complex; Benzoylthiourea; Hirshfeld surface
In this paper, the title compound was synthesized from N-benzoyl-N′,N′-dibenzylthiourea ligand and potassium tetrachloroplatinate(II), and its interaction with human (HSA) and bovine (BSA) serum albumin was evaluated. Also, the crystal structure was determined from single-crystal X‐ray diffraction, confirming that the platinum atom is coordinated with two chelated N-benzoyl-N′,N′-dibenzylthiourea ligands in a distorted square-planar geometry. In the solid state, Hirshfeld surface analysis emphasizes that the molecules are connected by non-classical C–H⋯C, C–H⋯S and H⋯H intermolecular contacts. These weak interactions can be mainly responsible due to complex-BSA and complex-HSA binding. The complex interacts differently with HSA and BSA such as observed by the binding constant, Kb, presenting values of around 105 M−1 and 104 M−1, respectively. Thermodynamic parameters (ΔG, ΔH and ΔS) suggest spontaneous interactions between complex and the proteins.
