Author(s): Bezerra, Vanessa Moraes ; Xavier, Carlos Henrique ; Fernandes, Luciano Gonçalves ; Cardoso, Leonardo Máximo ; Fontes, Marco Antônio Peliky ; Chianca Júnior, Deoclécio Alves
Date: 2012
Origin: Oasisbr
Subject(s): Bezold-Jarisch reflex; Sympathetic activity; Protein malnutrition
Malnutrition affects cardiovascular reflexes, including chemoreflex and baroreflex. In this study we assessed the hypothesis that malnourishment changes the responses in mean arterial pressure (MAP), heart rate (HR) and renal sympathetic nerve activity (RSNA) evoked from Bezold–Jarischreflex (BJR). Fischer rats were fed diets containing either (6% malnourished or 14% control) protein for 35 days after weaning. There were no differences in baseline MAP (102 ± 4 vs. 95 ± 3 mmHg) whereas higher baseline HR (478 ± 18 vs. 360 ± 11 bpm; P < 0.05,) and reduced sympathoinhibition (ΔRSNA = −54 ± 9 vs. −84 ± 7%; P = 0.0208) to BJR activation were found in malnourishedrats. We conclude that malnutrition affects the sympathetic control of BJR.
