Author(s): Butera, Anna Paola ; Souza Filho, José Dias de ; Carvalho, Diogo Teixeira ; Figueiredo, Rute Cunha ; Faria, Luiz Carlos Alves de ; Nunes, Maria Angélica Antunes ; Prado, Maria Auxiliadora Fontes ; Alves, Ricardo José ; Andrade, Milton Hércules Guerra de ; Rúbio, Karina Taciana Santos
Date: 2015
Origin: Oasisbr
Subject(s): Carbohydrates; Plant lectins; Amides
We report herein the synthesis of some -D-galactopyranosylamine and -lactosylamine amides and sulfonamides. The interactions of these compounds with lectins from the seeds of Erythrina cristagalli (LEC) and Ricinus communis (RCA120) were evaluated in a hemagglutination inhibitory activity assay. D-Galactose and lactose were used as reference compounds. The -lactosylamine amides and sulfonamides were nearly as active as lactose in inhibiting LEC mediated hemagglutination and were less active against RCA120 agglutinin. The -D-galactopyranosylamine amides and sulfonamides were, with one exception, considerably less active than Dgalactose in the assay with both lectins.
