Estudo qu?mico de Guatteria duckeana

• Author(s): Almeida, Pedro do Bom Despacho de
• Date: 2020
• Origin: Oasisbr
• Subject(s): Qu?mica; Qu?mica
• Document Type: Master thesis
• Language: Portuguese

Description

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Made available in DSpace on 2020-11-16T13:00:02Z (GMT). No. of bitstreams: 1 1986 - Pedro Bom Despacho de Almeida.pdf: 2628510 bytes, checksum: a888f97a200ff422e27e4248394db14e (MD5) Previous issue date: 1986-08-08

Coordena??o e Aperfei?oamento de Pessoal de N?vel Superior - CAPES

The chemicals constituents of the majority species of Annonaceae family, have economical, chemistry and medicinal importances, justifying the chemical study of some species that are not being s t u d i e d . For this reason, emerged the interest for the chemical study of Guatteria duckeana, after a revision from published subjects about the chemical family. The benzenic extract from the wood of this species provided a mixture of sytosterol, stygmasterol and 24 methyl-cholesterol (GD - 7P), N-acetylanonaine (GD - 1P), N-acetyl-puterine (GD - 2P), 1 vinyl-3,4-dimethoxy phenanthrene (GD - 3P), 1,2-methylenodioxy- -11 methoxy-7-oxo-aporphine (GD - 6P), 8-hidroxy-6-methoxy-3,5- dimethyl-3,4-dihydroisocoumarin (GD - 5P). The two last substances are products of fungus metabolism as the available wood in this study was infested by this microorganism. When the substance 1-vinyl-3,4-dimethoxy-phenanthrene (GD -3P) and alkaloids aporphinics occurred in Guatteria duckeana allowed the biogenetic creation for the phenanthrenic product. The constituents isolation involved chromatographycs methods. Spectrals features were used for the structural elucidation of the isolated substances.

Os constituintes qu?micos que se obt?m da maioria das esp?cies da fam?lia Annonaceae possuem import?ncias econ?mica, qu?mica e medicinal, fato que justifica o estudo qu?- mico de esp?cies ainda n?o estudadas. Por esta raz?o ap?s uma revis?o de dados publicados sobre a qu?mica da fam?lia, despertou-se o interesse para o estudo qu?mico de Guatteria duckeana. O extrato benz?nico da madeira desta esp?cie forneceu uma mistura de sitosterol, estigmasterol e 24-metil-colesterol (GD-7P), N-acetil-anonaina (GD-1P), N-acetil-puterina (GD-2P), 1-vinil-3,4-dimetoxi-fenantreno (GD-3P), 1,2-metilenodioxi-11-metoxi-7-oxo-apofina (GD-6P), 8-hidroxi-6-metoxi- -3,5-dimetil-3,4-diidroisocumarina (GD-4P) e 8-hidroxi-3,5- -dimetil-3,4-diidroisocumarina (GD-5P). As duas ?ltimas subst?ncias s?o produtos de metabolismo de fungo, admitindo que a madeira utilizada neste estudo foi infestada por este microorganismo. A ocorr?ncia da subst?ncia 1-vinil-3,4-dimetoxi-fenantreno (GD-3P) e alcal?ides aporf?nicos em Guatteria duckeana permitiu postula??o biogen?tica para o produto fenantr?nico. O isolamento dos constituintes envolveu m?todos cromatogr?ficos. Dados espectrais foram utilizados na elucida??o estrutural das subst?ncias isoladas.