Author(s): Silva, Romildo Torres da
Date: 2015
Origin: Oasisbr
Subject(s): tendinite; inflama????o aguda; tend??o calc??neo; colagenase; laser de baixa pot??ncia; tendinitis; acute inflammation; achilles tendon; collagenase; low intensity laser therapy; CIENCIAS DA SAUDE
Submitted by Nadir Basilio (nadirsb@uninove.br) on 2015-07-20T18:29:39Z No. of bitstreams: 1 Romildo Torres da Silva.pdf: 1197534 bytes, checksum: 02ae9c343d597dbbc37f2a71f43ad453 (MD5)
Made available in DSpace on 2015-07-20T18:29:39Z (GMT). No. of bitstreams: 1 Romildo Torres da Silva.pdf: 1197534 bytes, checksum: 02ae9c343d597dbbc37f2a71f43ad453 (MD5) Previous issue date: 2015-12-12
Tendinopathy is a common disease with a variety of treatments and therapies. Laser therapy appears as a alternative treatment. We research the effects of the laser irradiation in tendinitis model induced by collagenase injection on Achilles tendon rats, verified its action in important inflammatory markers. Methods: The male rats (Wistar) were used and divided in groups: Saline (C), Tendinitis (NT) and tendinitis treated with Sodium diclofenac (D) or Laser (1J) and (3J). The tendinitis was induced by collagenase (100??g/tendon) on the Achilles tendon which was removed for analyzes. The gene expression for COX-2; TNF-??; il-6 and IL-10 (RT-PCR) was measured. Results and discussion: The Laser therapy (660nm, 100mW, 3J) used in the treatment of the tendinitis induced by collagenase in Achilles tendon in rats, was effective in the reduction of important inflammatory markers, becoming a promising tool for the treatment of tendon diseases.
Tendinopatias s??o dist??rbios comuns com uma variedade de tratamentos e terapias e a Laserterapia aparece como uma alternativa no tratamento destas doen??as. N??s investigamos os efeitos da irradia????o laser no modelo de tendinite induzida por colagenase, em tend??es calc??neo de ratos, verificando sua a????o em importantes marcadores inflamat??rios. M??todos: Foram utilizados ratos machos (Wistar) divididos em grupos: Controle (C), Tendinite N??o Tratado (NT), Tratamento com Diclofenado de S??dio (D) ou Laser (1J) e (3J). A tendinite foi induzida por colagenase (100??g/tend??o) sobre o tend??o calc??neo que foi removido para an??lises. Foi verificado a express??o g??nica de COX-2, TNF-??, IL-6 e IL-10 (RT-PCR). Resultados e discuss??o: A laserterapia (660nm, 100mW, 3J), utilizada no tratamento da tendinite induzida por colagenase em tend??o calc??neo de ratos, foi eficaz na redu????o de importantes marcadores inflamat??rios, tornando-se uma ferramenta promissora para o tratamento de les??es tend??neas.
