Author(s): Oliveira, Ana Flávia Costa da Silveira ; Teixeira, Róbson Ricardo ; Oliveira, André Silva de ; Souza, Ana Paula Martins de ; Silva, Milene Lopes da ; Paula, Sérgio Oliveira de
Date: 2017
Origin: Oasisbr
Subject(s): Dengue; Chikungunya; Virus enzymes; Antiviral; Natural products
Dengue virus (DENV) and chikungunya virus (CHIKV) are reemergent arboviruses that are transmitted by mosquitoes of the Aedes genus. During the last several decades, these viruses have been responsible for millions of cases of infection and thousands of deaths worldwide. Therefore, several investigations were conducted over the past few years to find antiviral compounds for the treatment of DENV and CHIKV infections. One attractive strategy is the screening of compounds that target enzymes involved in the replication of both DENV and CHIKV. In this review, we describe advances in the evaluation of natural products targeting the enzymes involved in the replication of these viruses. View Full-Text
