Autor(es):
Ferreira, Wallax Augusto Silva ; Pinheiro, Danilo do Ros?rio ; Costa Junior, Carlos Antonio da ; Rodrigues, Symara Antunes ; Ara?jo, Mariana Diniz ; Barros, Mariceli Baia Le?o ; Teixeira, Adriana Corr?a de Souza ; Faro, Thamirys Aline Silva ; Burbano, Rommel Rodriguez ; Oliveira, Edivaldo Herculano Correa de ; Harada, Maria L?cia ; Borges, B?rbara do Nascimento
Data: 2017
Origem: Oasisbr
Assunto(s): Neoplasias Encef?licas; Biomarcadores / l?quido cefalorraquidiano; Carcinog?nese; Glioblastoma; Neoplasias Encef?licas; Metila??o de DNA; Epig?nese Gen?tica; Biomarcadores Tumorais; Astrocitoma
Descrição
Federal University of Par?. Institute of Biological Sciences. Molecular Biology Laboratory. Bel?m, PA, Brazil.
Federal University of Par?. Institute of Biological Sciences. Molecular Biology Laboratory. Bel?m, PA, Brazil.
Federal University of Par?. Institute of Biological Sciences. Molecular Biology Laboratory. Bel?m, PA, Brazil.
Federal University of Par?. Institute of Biological Sciences. Molecular Biology Laboratory. Bel?m, PA, Brazil.
Federal University of Par?. Institute of Biological Sciences. Molecular Biology Laboratory. Bel?m, PA, Brazil.
Federal University of Par?. Institute of Biological Sciences. Molecular Biology Laboratory. Bel?m, PA, Brazil.
Federal University of Par?. Institute of Biological Sciences. Molecular Biology Laboratory. Bel?m, PA, Brazil.
Federal University of Par?. Institute of Biological Sciences. Molecular Biology Laboratory. Bel?m, PA, Brazil.
Federal University of Par?. Institute of Biological Sciences. Human Cytogenetics Laboratory. Bel?m, PA, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Federal University of Par?. Institute of Biological Sciences. Molecular Biology Laboratory. Bel?m, PA, Brazil.
Federal University of Par?. Institute of Biological Sciences. Molecular Biology Laboratory. Bel?m, PA, Brazil.
Glioblastomas, also known as glioblastoma multiforme (GBM), are the most aggressive and malignant type of primary brain tumor in adults, exhibiting notable variability at the histopathological, genetic and epigenetic levels. Recently, epigenetic alterations have emerged as a common hallmark of many tumors, including GBM. Considering that a deeper understanding of the epigenetic modifications that occur in GBM may increase the knowledge regarding the tumorigenesis, progression and recurrence of this disease, in this review we discuss the recent major advances in GBM epigenetics research involving histone modification, glioblastoma stem cells, DNA methylation, noncoding RNAs expression, including their main alterations and the use of epigenetic therapy as a valid option for GBM treatment.
