Autor(es): Palacios, Gustavo ; Tesh, Robert ; Rosa, Am?lia Paes de Andrade Travassos da ; Savji, Nazir ; Sze, Wilson ; Jain, Komal ; Serge, Robert ; Guzman, Hilda ; Guevara, Carolina ; Nunes, M?rcio Roberto Teixeira ; Nunes Neto, Joaquim P ; Kochel, Tadeusz ; Hutchison, Stephen ; Vasconcelos, Pedro Fernando da Costa ; Lipkin, W. Ian
Data: 2017
Origem: Oasisbr
Assunto(s): Bunyaviridae / classifica??o; Phlebovirus / classifica??o; Infec??es por Bunyaviridae
This study was supported by Google.org, National Institutes of Health award AI57158 (Northeast Biodefense Center [W.I.L.]), and USAID Predict funding source code 07-301-7119-52258 (Center for Infection and Immunity) and the Department of Defense. R.T., A.T.R., and H.G. were supported by NIH contracts NO1-AI30027 and HHSN272201000040I/HHSN27200004/D04. M.R.T.N., J.P.N.-N., and P.F.C.V. were supported by CNPq grants 300460/2005-8, 483453/ 2007-2, and 302987/2008-8. This study was partially funded by the U.S. Department of Defense Global Emerging Infections Systems Research Program (work unit number 847705?82000?25GB.B0016).
Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, NY, USA.
University of Texas Medical Branch. Department of Pathology. Center for Biodefense and Emerging Infectious Disease. Galveston, TX, USA.
University of Texas Medical Branch. Department of Pathology. Center for Biodefense and Emerging Infectious Disease. Galveston, TX, USA.
Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, NY, USA.
Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, NY, USA.
Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, NY, USA.
Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, NY, USA.
University of Texas Medical Branch. Department of Pathology. Center for Biodefense and Emerging Infectious Disease. Galveston, TX, USA.
U.S. Naval Medical Research Center Detachment. Lima, PE.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
U.S. Naval Medical Research Center Detachment. Lima, PE.
Roche Life Sciences. Branford, CT, USA.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil / Par? State University. Department of Pathology. Bel?m , PA, Brazil.
Columbia University. Mailman School of Public Health. Center for Infection and Immunity. New York, NY, USA.
The genus Phlebovirus of the family Bunyaviridae consists of approximately 70 named viruses, currently assigned to nine serocomplexes (species) based on antigenic similarities. Sixteen other named viruses that show little serologic relationship to the nine recognized groups are also classified as tentative species in the genus. In an effort to develop a more precise classification system for phleboviruses, we are attempting to sequence most of the named viruses in the genus with the goal of clarifying their phylogenetic relationships. In this report, we describe the serologic and phylogenetic relationships of 13 viruses that were found to be members of the Candiru serocomplex; 6 of them cause disease in humans. Analysis of full genome sequences revealed branching inconsistencies that suggest five reassortment events, all involving the M segment, and thus appear to be natural reassortants. This high rate of reassortment illustrates the inaccuracy of a classification system based solely on antigenic relationships.
