Autor(es):
Contreras-Guti?rrez, Mar?a Ang?lica ; Nunes, M?rcio Roberto Teixeira ; Guzman, Hilda ; Uribe, Sandra ; Vasco, Juan David Suaza ; Cardoso, Jedson F ; Popov, Vsevolod L ; Widen, Steven G ; Wood, Thomas G ; Vasilakis, Nikos ; Tesh, Robert B
Data: 2017
Origem: Oasisbr
Assunto(s): Culicidae / virologia; Orthomyxoviridae / classifica??o; Orthomyxoviridae / qu?mica; Orthomyxoviridae / gen?tica; Orthomyxoviridae / isolamento & purifica??o; Orthomyxoviridae / ultraestrutura; Thogotovirus / classifica??o; Thogotovirus / qu?mica; Thogotovirus / gen?tica; Thogotovirus / isolamento & purifica??o; Thogotovirus / ultraestrutura; Prote?nas Virais / gen?tica; Prote?nas Virais / qu?mica; Prote?nas Virais / metabolismo; Evolu??o Molecular; Modelos Moleculares; Genoma Viral; Filogenia; Sequ?ncia de Amino?cidos; Dados de Sequ?ncia Molecular; T?cnica Indireta de Fluoresc?ncia para Anticorpo / M?todos; Rea??o em Cadeia da Polimerase Via Transcriptase Reversa / m?todos; Col?mbia
Descrição
Universidad de Antioquia. SIUSde de Investigaci?n Universitaria. Programa de Estudio y Control de Enfermedades Tropicales - PECET. Medell?n, Colombia / Universidad Nacional de Colombia. Facultad de Ciencias. Grupo de Investigaci?n en Sistem?tica Molecular. Medell?n, Colombia.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Centro de Inova??es Tecnol?gicas. Ananindeua, PA, Brasil.
University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston, TX, USA.
Universidad Nacional de Colombia. Facultad de Ciencias. Grupo de Investigaci?n en Sistem?tica Molecular-GSM. Medell?n, Colombia.
Universidad de Antioquia. Grupo de Investigaci?n en Medicina Molecular y Traslacional. Medell?n, Colombia.
Universidad de Antioquia. SIUSde de Investigaci?n Universitaria. Programa de Estudio y Control de Enfermedades Tropicales - PECET. Medell?n, Colombia
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Centro de Inova??es Tecnol?gicas. Ananindeua, PA, Brasil.
University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston, TX, USA.
University of Texas Medical Branch. Department of Biochemistry and Molecular Biology. Galveston, TX, USA.
University of Texas Medical Branch. Department of Biochemistry and Molecular Biology. Galveston, TX, USA.
University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston, TX, USA.
University of Texas Medical Branch. Institute for Human Infections and Immunity. Department of Pathology. Galveston, TX, USA.
The genome and structural organization of a novel insect-specific orthomyxovirus, designated Sinu virus, is described. Sinu virus (SINUV) was isolated in cultures of C6/36 cells from a pool of mosquitoes collected in northwestern Colombia. The virus has six negative-sense ssRNA segments. Genetic analysis of each segment demonstrated the presence of six distinct ORFs encoding the following genes: PB2 (Segment 1), PB1, (Segment 2), PA protein (Segment 3), envelope GP gene (Segment 4), the NP (Segment 5), and M-like gene (Segment 6). Phylogenetically, SINUV appears to be most closed related to viruses in the genus Thogotovirus.
