Autor(es):
Justino, Maria Cleonice Aguiar ; Brasil, Patr?cia ; Abreu, Erika ; Miranda, Yllen ; Mascarenhas, Joana D'Arc Pereira ; Guerra, Sylvia de F?tima dos Santos ; Linhares, Alexandre da Costa
Data: 2018
Origem: Oasisbr
Assunto(s): Gastroenterite / preven??o & controle; Gastroenterite / virologia; Infec??es por Rotavirus / preven??o & controle; Rotavirus / imunologia; Vacinas contra Rotavirus / uso terap?utico; ?ndice de Gravidade de Doen?a; Resultado do Tratamento; Estudos Prospectivos; Ensaio de Imunoadsor??o Enzim?tica / m?todos; Doen?a Aguda
Descrição
This work was supported by Instituto Evandro Chagas, Health Surveillance Secretariat, Brazilian Ministry of Health
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Funda??o Oswaldo Cruz. Instituto de Pesquisa Cl?nica. Rio de Janeiro, RJ, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
In March 2006, Brazil introduced the monovalent rotavirus (RV) vaccine (RotarixTM) into the public sector. This study assessed the severity of rotavirus gastroenteritis (RVGE) according to the vaccination status among hospitalized children. We identified 1023 RVGE episodes among not vaccinated (n ? 252), partially vaccinated (n ? 156) and fully vaccinated (n ? 615) children. Very severe gastroenteritis (scored 15) was reported in 16.7, 17.9 and 13.5% of not vaccinated, partially vaccinated and fully vaccinated children, respectively. There was a trend for a shorter duration of RV diarrhoea among vaccinated children than in not vaccinated children (p ? 0.07). A protective effect of vaccination was noted when mean duration of symptoms and hospital stay are analysed, comparing unvaccinated, partially vaccinated and fully vaccinated children (p < 0.05). We showed a vaccination dose effect trend, with fully vaccinated children having less-severe RVGE than not vaccinated and partially vaccinated children.
