Autor(es): Gabbay, Yvone Benchimol ; Chamone, Chequer Buffe ; Nakamura, Liliany Satiko ; Oliveira, Darleise de Souza ; Abreu, Simone Faria de ; Pepino, Elielma Lira Cavalcante ; Mascarenhas, Joana D'Arc Pereira ; Leite, Jos? Paulo Gagliardi ; Linhares, Alexandre da Costa
Data: 2018
Origem: Oasisbr
Assunto(s): Mamastrovirus / gen?tica; Mamastrovirus / isolamento & purifica??o; Surtos de Doen?as; M?todos Epidemiol?gicos; Minas Gerais (MG); Reserva Maxakali (MG)
This work received financial support from IEC-SVS, FUNTEC/PA, CNPq and FIOCRUZ
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil.
Funda??o Ezequiel Dias. Instituto Oct?vio Magalh?es. Divis?o de Epidemiologia e Controle de Doen?as. Belo Horizonte, MG, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil.
Secretaria de Estado da Sa?de Minas Gerais. Coordena??o do Programa de Sa?de Ind?gena de Minas Gerais. Belo Horizonte, MG, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil.
Funda??o Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Laborat?rio de Virologia Comparada. Rio de Janeiro, RJ, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil.
BACKGROUND: Human astroviruses (HAstVs) are a common cause of sporadic diarrhea in children but large outbreaks occur in children's day care centers, schools and in homes for the elderly. OBJECTIVES: To report a large outbreak of acute gastroenteritis that occurred in January 2004 among Indians from the Maxakali Reserve in the State of Minas Gerais, Brazil. STUDY DESIGN: Fecal samples from 46 Maxakali patients were collected and tested for a range of enteric pathogens. HAstVs was detected by EIA and strains were confirmed by RT-PCR and typed by direct sequencing. Clinical information was collected. RESULTS: The illness which affected more than 100 children under 6 years of age was characterized by watery diarrhea, fever and vomiting. HAstV-2 was the sole enteropathogen detected in 26 (56%) of 46 samples analyzed by EIA and/or RT-PCR. The 17 positive samples sequenced were identical in a 348bp region used for phylogenetic analysis and were classified as genotype 2. CONCLUSIONS: This is the first description of an outbreak of HAstV-2 gastroenteritis in a population of Brazilian Indians. The magnitude of the outbreak and the severity of the disease underscore the need to better understand the epidemiology of astrovirus and other enteric agents in these populations.
