Author(s): Freitas, Ronaldo Barros de ; Durigon, Edison Luiz ; Oliveira, Darleise de Souza ; Romano, Camila Malta ; Freitas, Maria Rute Castro ; Linhares, Alexandre da Costa ; Melo, Fernando Lucas ; Walshkeller, L?lian ; Barbosa, Maria Luiza ; Huatuco, Egma M. Mayta ; Holmes, Edward C ; Zanotto, Paolo Marinho de A
Date: 2018
Origin: Oasisbr
Subject(s): Parvovirus B19 Humano; Filogenia
This study was supported by CNPq, MCT and FAPESP projects 00/04205-06 and 00/11511-06-VGDN program. ELD and PMAZ hold a PQ-CNPq scholarship. CMR and FLM hold a CAPES scholarship
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil.
Universidade de S?o Paulo. Instituto de Ci?ncias Biom?dicas. Departamento de Micobiologia. Laborat?rio de Virologia Clinica. S?o Paulo, SP, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil.
Universidade de S?o Paulo USP. Departamento de Microbiologia. Laborat?rio de Evolu??o Molecular e Bioinform?tica. S?o Paulo, SP, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Bel?m, PA, Brasil.
Universidade de S?o Paulo USP. Departamento de Microbiologia. Laborat?rio de Evolu??o Molecular e Bioinform?tica. S?o Paulo, SP, Brazil.
Universidade de S?o Paulo. Instituto de Ci?ncias Biom?dicas. Departamento de Micobiologia. Laborat?rio de Virologia Clinica. S?o Paulo, SP, Brazil.
Instituto Adolfo Lutz. S?o Paulo, SP, Brazil.
University of San Marcos. Lima, Peru.
The Pennsylvania State University. Department of Biology. Center for Infectious Disease Dynamics. University Park, PA, USA.
Universidade de S?o Paulo USP. Departamento de Microbiologia. Laborat?rio de Evolu??o Molecular e Bioinform?tica. S?o Paulo, SP, Brazil.
To understand the evolutionary dynamics of human parvovirus B19, we analyzed VP1 and VP2 gene sequences of B19 sampled from Bel?m (Amazon), the city of S?o Paulo, Brazil and globally. Our analysis revealed a strikingly different pattern of evolutionary change for those viral lineages introduced into Bel?m, which exhibited a higher rate of nonsynonymous substitutions compared to those viruses sampled from other locations. We propose that difference this is due to the high prevalence of B19 in Belem (up to 85 per cent) compared to other locations (prevalence?s of approximately 50 per cent), which imposes a more intense selection pressure. Hence, those B19 lineages introduced into Belem experienced an elevated rate of amino acid change, driven by positive selection, in order to generate serial re-infections in a small web of transmission, which can be thought of as an evolutionary "pressure pan"
