Autor(es):
Costa, Carlos Araujo da ; Furtado, Karen Cristini Yumi Ogawa ; Ferreira, Louise de Souza Canto ; Almeida, Danilo de Souza ; Linhares, Alexandre da Costa ; Ishak, Ricardo ; Vallinoto, Antonio Carlos Ros?rio ; Lemos, Jos? Alexandre Rodrigues de ; Martins, Luisa Caricio ; Ishikawa, Edna Aoba Yassui ; Sousa, Rita Catarina Medeiros de ; Sousa, Ma?sa Silva de
Data: 2018
Origem: Oasisbr
Assunto(s): Deltaretrovirus / patogenicidade; Estudos Transversais; Ensaio de Imunoadsor??o Enzim?tica - m?todos; Infec??es por Deltaretrovirus
Descrição
The authors want to thank PPSUS/FAPESPA/CNPq (PROJ_428_9577372) and CAPES and PROPESP/UFPA and PADESP. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Universidade Federal do Par?. N?cleo de Medicina Tropical. Bel?m, PA, Brazil.
Universidade Federal do Par?. N?cleo de Medicina Tropical. Bel?m, PA, Brazil.
Universidade Federal do Par?. N?cleo de Medicina Tropical. Bel?m, PA, Brazil.
Universidade Federal do Par?. N?cleo de Medicina Tropical. Bel?m, PA, Brazil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Bel?m, PA, Brazil.
Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Bel?m, PA, Brazil.
Universidade Federal do Par?. Instituto de Ci?ncias Biol?gicas. Bel?m, PA, Brazil.
Universidade Federal do Par?. N?cleo de Medicina Tropical. Bel?m, PA, Brazil.
Universidade Federal do Par?. N?cleo de Medicina Tropical. Bel?m, PA, Brazil.
Universidade Federal do Par?. N?cleo de Medicina Tropical. Bel?m, PA, Brazil / Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Universidade Federal do Par?. N?cleo de Medicina Tropical. Bel?m, PA, Brazil / Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Background: HTLV-1 is a retrovirus that causes lymphoproliferative disorders and inflammatory and degenerative diseases of the central nervous system in humans. The prevalence of this infection is high in parts of Brazil and there is a general lack of public health care programs. As a consequence, official data on the transmission routes of this virus are scarce. Objective: To demonstrate familial aggregation of HTLV infections in the metropolitan region of Bel?m, Par? , Brazil. Method: A cross-sectional study involving 85 HTLV carriers treated at an outpatient clinic and other family members. The subjects were tested by ELISA and molecular methods between February 2007 and December 2010. Results: The prevalence of HTLV was 43.5 per cent (37/85) for families and 25.6 per cent (58/227) for the family members tested (95 per cent CI:1.33 to 3.79, P = 0.0033). Sexual and vertical transmission was likely in 38.3 per cent (23/60) and 20.4 per cent (29/142) of pairs, respectively (95 per cent CI: 1.25 to 4.69, P = 0.0130). Positivity was 51.3 per cent (20/39) and 14.3 per cent (3/21) in wives and husbands, respectively (95 per cent CI:0.04 to 0.63, P = 0.0057). By age group, seropositivity was 8.0 per cent (7/88) in subjects ,30 years of age and 36.7 per cent (51/139) in those of over 30 years (95 per cent CI: 0.06 to 0.34, P,0.0001). Positivity was 24.1 per cent (7/29) in the children of patients infected with HTLV-2, as against only 5.8 per cent (4/69) of those infected with HTLV-1 (95 per cent CI: 0.05 to 0.72, P = 0.0143). Conclusion: The results of this study indicate the existence of familial aggregations of HTLV characterized by a higher prevalence of infection among wives and subjects older than 30 years. Horizontal transmission between spouses was more frequent than vertical transmission. The higher rate of infection in children of HTLV-2 carriers suggests an increase in the prevalence of this virus type in the metropolitan region of Bel?m.
