Autor(es): Souza, William Marciel de ; Fumagalli, Marc?lio Jorge ; Santos Jr, Gilberto Sabino ; Maia, Felipe Gon?alves Motta ; Modha, Sejal ; Nunes, M?rcio Roberto Teixeira ; Murcia, Pablo Ramiro ; Figueiredo, Luiz Tadeu Moraes
Data: 2019
Origem: Oasisbr
Assunto(s): Hepacivirus / isolamento & purifica??o; Hepatite C / patologia; Flaviviridae / patogenicidade; Arvicolinae / virologia; Camundongos; Doen?as dos Roedores / virologia
This research was funded by Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo, Brazil (Grant number No. 13/14929-1, and Scholarships No. 12/24150-9; 15/05778-5; 17/13981-0; 16/01414-1; 08/06411-4; 11/06810-9; 11/22663-6; 16/02568-2). PRM was supported by the Medical Research Council of the United Kingdom (Grant MC_UU_120/14/9).
University of S?o Paulo. Ribeir?o Preto Medical School. Virology Research Center. Ribeir?o Preto, SP, Brazil / MRC-University of Glasgow Centre for Virus Research. Glasgow, UK / University of Campinas. Institute of Biology. Department of Genetics, Evolution and Bioagents. Campinas, SP, Brazil.
University of S?o Paulo. Ribeir?o Preto Medical School. Virology Research Center. Ribeir?o Preto, SP, Brazil.
University of S?o Paulo. Ribeir?o Preto Medical School. Virology Research Center. Ribeir?o Preto, SP, Brazil
University of S?o Paulo. Ribeir?o Preto Medical School. Virology Research Center. Ribeir?o Preto, SP, Brazil / University of S?o Paulo. Institute of Biomedical Sciences. S?o Paulo, SP, Brazil.
MRC-University of Glasgow Centre for Virus Research. Glasgow, UK.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Centro de Inova??es Tecnol?gicas.Ananindeua, PA, Brasil.
MRC-University of Glasgow Centre for Virus Research. Glasgow, UK.
University of S?o Paulo. Ribeir?o Preto Medical School. Virology Research Center. Ribeir?o Preto, SP, Brazil.
The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from S?o Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus.
