Autor(es):
Tahira, Ana Carolina ; Barbosa, Andr? Rocha ; Feltrin, Arthur Sant'Anna ; Gastaldi, Vinicius Daguano ; Toledo, Victor Hugo Calegari de ; Pereira, Jos? Geraldo de Carvalho ; Lisboa, Bianca Cristina Garcia ; Reis, Viviane Neri de Souza ; Santos, Ana Cecilia Feio dos ; Maschietto, Mariana ; Brentani, Helena
Data: 2019
Origem: Oasisbr
Assunto(s): Transtornos do Neurodesenvolvimento / gen?tica; Transtorno do Espectro Autista; Transtorno Aut?stico / gen?tica; Fatores de Transcri??o SOX / gen?tica; Cromossomo Y / gen?tica; Genes sry / gen?tica; Caracteres Sexuais; Estresse Psicol?gico
Descrição
Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior, Grant/Award Number: DS ProgramDS-1750212PROEX-1 669479PROEX-33002010073P7; Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo, Grant/Award Number: 2011/04956-62011/ 14658-22014/00041-12014/00591-12014/ 10488-32015/06281-7; Universidade Federal do ABC, Grant/Award Number: Institutional Scholarship; UFABC; CAPES, Grant/Award Number: DS-1750212; FAPESP, Grant/Award Numbers: 2014/10488-3, 2011/04956-6, 2014/00591-1, 2014/00041-1, 2015/06281-7, 2011/14658-2.
Universidade de S?o Paulo. Faculdade de Medicina. Hospital das Clinicas. Instituto de Psiquiatria. Laborat?rio de Psicopatologia e Terap?utica Psiqui?trica. S?o Paulo, SP, Brazil.
Universidade de S?o Paulo. Faculdade de Medicina. Hospital das Clinicas. Instituto de Psiquiatria. Laborat?rio de Psicopatologia e Terap?utica Psiqui?trica. S?o Paulo, SP, Brazil / University of S?o Paulo. Inter-institutional Grad Program on Bioinformatics. S?o Paulo, SP, Brazil.
Federal University of ABC. Center of Mathematics, Computing and Cognition. Santo Andr?, SP, Brazil.
Universidade de S?o Paulo. Faculdade de Medicina. Hospital das Clinicas. Instituto de Psiquiatria. Laborat?rio de Psicopatologia e Terap?utica Psiqui?trica. S?o Paulo, SP, Brazil.
Universidade de S?o Paulo. Faculdade de Medicina. Hospital das Clinicas. Instituto de Psiquiatria. Laborat?rio de Psicopatologia e Terap?utica Psiqui?trica. S?o Paulo, SP, Brazil.
Brazilian Center for Research in Energy and Materials. Brazilian Biosciences National Laboratory. Campinas, SP, Brazil.
Universidade de S?o Paulo. Faculdade de Medicina. Hospital das Clinicas. Instituto de Psiquiatria. Laborat?rio de Psicopatologia e Terap?utica Psiqui?trica. S?o Paulo, SP, Brazil.
Universidade de S?o Paulo. Faculdade de Medicina. Hospital das Clinicas. Instituto de Psiquiatria. Laborat?rio de Psicopatologia e Terap?utica Psiqui?trica. S?o Paulo, SP, Brazil.
Universidade de S?o Paulo. Faculdade de Medicina. Hospital das Clinicas. Instituto de Psiquiatria. Laborat?rio de Psicopatologia e Terap?utica Psiqui?trica. S?o Paulo, SP, Brazil / Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Laborat?rio de Pesquisas B?sicas em Mal?ria ? Entomologia. Ananindeua, PA, Brasil.
Brazilian Center for Research in Energy and Materials. Brazilian Biosciences National Laboratory. Campinas, SP, Brazil.
Universidade de S?o Paulo. Faculdade de Medicina. Hospital das Clinicas. Instituto de Psiquiatria. Laborat?rio de Psicopatologia e Terap?utica Psiqui?trica. S?o Paulo, SP, Brazil / University of S?o Paulo. Inter-institutional Grad Program on Bioinformatics. S?o Paulo, SP, Brazil / Universidade de S?o Paulo. Faculdade de Medicina. Hospital das Clinicas. Instituto de Psiquiatria. S?o Paulo, SP, Brazil / National Institute of Developmental Psychiatry for Children and Adolescents. S?o Paulo, SP, Brazil / Universidade de S?o Paulo. Faculdade de Medicina. S?o Paulo, SP, Brazil.
The male-biased prevalence of certain neurodevelopmental disorders and the sex-biased outcomes associated with stress exposure during gestation have been previously described. Here, we hypothesized that genes distinctively targeted by only one or both homologous proteins highly conserved across therian mammals, SOX3 and SRY, could induce sexual adaptive changes that result in a differential risk for neurodevelopmental disorders. ChIP-seq/chip data showed that SOX3/SRY gene targets were expressed in different brain cell types in mice. We used orthologous human genes in rodent genomes to extend the number of SOX3/SRY set (1,721). These genes were later found to be enriched in five modules of coexpressed genes during the early and mid-gestation periods (FDR?
