Autor(es): Lopes, Bruna Pedroso Tameg?o ; Sousa J?nior, Edivaldo Costa ; Passetti, Fabio ; Ferreira, Carlos Gil ; Mello, Wyller Alencar de ; Silvestre, Rodrigo Vellasco Duarte
Data: 2016
Origem: Oasisbr
Assunto(s): Infec??es por Papillomavirus; Papillomavirus Humano 16 / isolamento & purifica??o; Preval?ncia; Regi?o Norte (BR)
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Instituto Nacional de C?ncer. Clinical Research Coordination. Rio de Janeiro, RJ, Brasil.
Instituto Nacional de C?ncer. Clinical Research Coordination. Rio de Janeiro, RJ, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.
Background: The main cause of cervical cancer in the world is high risks human papillomavirus infection (mainlyrepresented by HPV-16 and HPV-18), that are associated to the development of malign transformation of the epithelium. HPV prevalence exhibits a wide geographical variability and HPV-16 variants have been related to an increased risk of developing cervical intraepithelial lesion. The aim of this study was to describe DNA-HPV prevalence and HPV-16 variants among a women population from Northern Brazil. Methods: One hundred and forty three women, during routine cervical cancer screening, at Juruti Project, fulfilled an epidemiological inquiry and were screened through a molecular HPV test. HPV-16 variants were determined by sequencing the HPV-16 E6 open reading frame. Results: Forty two samples were considered HPV positive (29.4 per cent). None of those had abnormal cytology results. HPV prevalence varied between different age groups (Z(U) = 14.62; p = >0.0001) and high-risk HPVs were more frequent among younger ages. The most prevalent type was HPV-16 (14 per cent) and it variants were classified, predominantly, as European (87.5 per cent). Conclusions: HPV prevalence in our population was higher than described by others and the most prevalent HPV types were high-risk HPVs. The European HPV-16 variant was the most prevalent among HPV-16 positive samples. Our study reinforces the fact that women with normal cytology and a positive molecular test for high-risk HPVs should be submitted to continuous follow up, in order to verify persistence of infection, promoting an early diagnosis of cervical cancer and/or its precursors.
