Author(s): Sousa, Erlânio Oliveira de ; Rodrigues, Fabíola Fernandez Galvão ; Campos, Adriana Rolim ; Costa, José Galberto Martins da
Date: 2015
Origin: Oasisbr
Subject(s): Lantana camara L.; antibacterial activity; aminoglycosides; synergism.; Microbiologia
Several plants have been evaluated not only for alone antimicrobial activity, but as resistance-modifying agent. This work is the first on the modulation of antibiotic activity by Lantana camara L. extracts against multiresistant strains of Escherichia coli and Staphylococcus aureus. The antibacterial activities of leaf and root ethanol extracts alone or in association with aminoglycosides were determined against bacterial strains by a microdilution test. The minimum inhibitory concentration (MIC) of the extracts was compared with of the aminoglycosides. Phytochemical prospection revealed the presence of quinones, steroids, flavonoids, saponins, tannins, triterpenoids and alkaloids. The results showed antibacterial activities of the extracts and synergistic effects combined with aminoglycosides. The most expressive effects were obtained with root extract but gentamicin or but neomycin against E. coli with MICs decreased (312 to 5 µg mL-1). The data from this study are indicative of the antibacterial activity of L. camara’s extracts and its potential in modifying the resistance of aminoglycosides analyzed.
