Author(s): Marinho, Patrícia ; Correia, Patrícia Carla dos Santos
Date: 2018
Persistent ID: http://hdl.handle.net/10400.22/22176
Origin: Repositório Científico do Instituto Politécnico do Porto
Subject(s): Diazepam suspensions; Chemical stability; Validation tests; Dosing method; Expiration date
Currently, hospital pharmacies prepare formulations that aim to adjust the medication to the needs of each patient when the pharmaceutical industry is not able to respond to those needs. One of the formulations produced in the hospital pharmacy is the diazepam suspension 0.4 mg/ml for paediatric use, obtained from diazepam tablets. However, the use of tablets or powders in oral liquid formulations may alter the stability of the active ingredients. Therefore, these formulations should be submitted to stability studies. Nevertheless, the information on the stability of manipulated oral suspensions is scarce, so this study is relevant.
