Autor(es): Rodrigues, Lia ; Paula, Arnaud Da Cruz ; Soares, Paula ; Vinagre, João
Data: 2024
Identificador Persistente: http://hdl.handle.net/10400.22/25531
Origem: Repositório Científico do Instituto Politécnico do Porto
Assunto(s): microRNAs E518K; Thyroid cancer; DGCR8; E518K
MicroRNAs (miRNAs) act as negative regulators for protein-coding gene expression impacting cell proliferation, differentiation, and survival. These miRNAs are frequently dysregulated in cancer and constitute classes of blood-based biomarkers useful for cancer detection and prognosis definition. In thyroid cancer (TC), the miRNA biogenesis pathway plays a pivotal role in thyroid gland formation, ensuring proper follicle development and hormone production. Several alterations in the miRNA biogenesis genes are reported as a causality for miRNA dysregulation. Mutations in microprocessor component genes are linked to an increased risk of developing TC; in particular, a recurrent mutation affecting DGCR8, the E518K. In this review, we explore these novel findings and resume the current state-of-the-art in miRNAs in thyroid carcinomas.
