Autor(es):
Elhakeem, A ; Taylor, AE ; Inskip, HM ; Huang, JY ; Mansell, T ; Rodrigues, C ; Asta, F ; Blaauwendraad, SM ; Haberg, SE ; Halliday, J ; Harskamp-van Ginkel, MW ; He, JR ; Jaddoe, VWV ; Lewis, S ; Maher, GM ; Manios, Y ; McCarthy, FP ; Reiss, IKM ; Rusconi, F ; Salika, T ; Tafflet, M ; Qiu, X ; Asvold, BO ; Burgner, D ; Chan, JKY ; Gagliardi, L ; Gaillard, R ; Heude, B ; Magnus, MC ; Moschonis, G ; Murray, D ; Nelson, SM ; Porta, D ; Saffery, R ; Barros, H ; Eriksson, JG ; Vrijkotte, TGM ; Lawlor, DA
Data: 2023
Identificador Persistente: https://hdl.handle.net/10216/154288
Origem: Repositório Aberto da Universidade do Porto
Assunto(s): Blood pressure; Glucose; In vitro fertilization; Lipids; Meta-analysis; Pooled longitudinal trajectory analysis
Descrição
Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. Methods and results Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 population-based birth cohorts in Europe, Australia, and Singapore, and results were combined using meta-analysis. Change in cardiometabolic outcomes from 2 to 26 years was examined using trajectory modelling of four cohorts with repeated measures. 35 938 (654 ART) offspring were included in the meta-analysis. Mean age ranged from 13 months to 27.4 years but was <10 years in 11/14 cohorts. Meta-analysis found no statistical difference (ART minus NC) in SBP (-0.53 mmHg; 95% CI:-1.59 to 0.53), DBP (-0.24 mmHg; -0.83 to 0.35), or HR (0.02 beat/min; -0.91 to 0.94). Total cholesterol (2.59%; 0.10-5.07), HDL cholesterol (4.16%; 2.52-5.81), LDL cholesterol (4.95%; 0.47-9.43) were statistically significantly higher in ART-conceived vs. NC offspring. No statistical difference was seen for triglycerides (TG), glucose, insulin, and glycated haemoglobin. Long-term follow-up of 17 244 (244 ART) births identified statistically significant associations between ART and lower predicted SBP/DBP in childhood, and subtle trajectories to higher SBP and TG in young adulthood; however, most differences were not statistically significant. Conclusion These findings of small and statistically non-significant differences in offspring cardiometabolic outcomes should reassure people receiving ART. Longer-term follow-up is warranted to investigate changes over adulthood in the risks of hypertension, dyslipidaemia, and preclinical and clinical cardiovascular disease.
