Synergistic effects between macrocyclic diterpenes and doxorubicin on resistant cancer cells

• Autor(es): Duarte, N ; Járdánházy, A ; Ramalhete, Cátia ; Molnar, J ; Ferreira, MJU
• Data: 2012
• Identificador Persistente: http://hdl.handle.net/10884/475
• Origem: Repositório Científico Atlântica
• Assunto(s): Diterpenes; Epirubicine; Cancer
• Tipo de Documento: Objeto de conferência
• Idioma: Inglês

Descrição

The aim of this study was to search for new multidrug resistance reversal agents from Euphorbia species. In this way, three new jatophane diterpenes (1 – 3) isolated from E.tuckeyana (Fig. 1) and three new lathyrane esters (4 - 6) obtained through acylation reations of latilagascene B (Fig. 4), have been screened for their potential P-gp modulating properties on mouse resistance cancer cell lines. Furthermore, in the combination chemotherapy model, the interaction between the cytostatic epirubicine and the six diterpenes were also evaluated.