IL10 Low-Frequency Variants in Behçet's Disease Patients

• Author(s): Matos, M ; Xavier, JM ; Abrantes, P ; Sousa, I ; Rei, N ; Davatchi, F ; Shahram, F ; Jesus, G ; Barcelos, F ; Vedes, J ; Salgado, Manuel ; Abdollahi, B ; Nadji, A ; Moraes-Fontes, MF ; Shafiee, N ; Ghaderibarmi, F ; Vaz Patto, J ; Crespo, J ; Oliveira, SA
• Date: 2014
• Persistent ID: http://hdl.handle.net/10400.17/2548
• Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Subject(s): Behçet's disease; IL10; Low-frequency variants; HCC DAUTOIM
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório da Unidade Local de Saúde São José

Description

To explain the missing heritability after the genome-wide association studies era, sequencing studies allow the identification of low-frequency variants with a stronger effect on disease risk. Common variants in the interleukin 10 gene (IL10) have been consistently associated with Behçet's disease (BD) and the goal of this study is to investigate the role of low-frequency IL10 variants in BD susceptibility.