Fatal Meningitis in Patient with X-Linked Chronic Granulomatous Disease Caused by Virulent Granulibacter bethesdensis

• Author(s): Rebelo, M ; Ding, L ; Cordeiro, AI ; Neves, C ; Simões, MJ ; Zelazny, AM ; Holland, SM ; Neves, JF
• Date: 2019
• Persistent ID: http://hdl.handle.net/10400.17/3489
• Origin: Repositório do Centro Hospitalar de Lisboa Central, EPE
• Subject(s): Adolescent; Animals; Disease Models, Animal; Fatal Outcome; Gram-Negative Bacterial Infections; Granulomatous Disease, Chronic; Humans; Magnetic Resonance Imaging; Male; Meningitis, Bacterial; Mice; Mice, Knockout; RNA, Ribosomal, 16S; Radiography, Thoracic; Virulence; Acetobacteraceae; HDE PED
• Document Type: Journal article
• Language: English
• Contributor(s): Repositório da Unidade Local de Saúde São José

Description

Granulibacter bethesdensis is a pathogen reported to cause recurrent lymphadenitis exclusively in persons with chronic granulomatous disease. We report a case of fatal meningitis caused by a highly virulent G. bethesdensis strain in an adolescent in Europe who had chronic granulomatous disease.