Autor(es):
Reschke, F ; Lanzinger, S ; Herczeg, V ; Prahalad, P ; Schiaffini, R ; Mul, D ; Clapin, H ; Zabeen, B ; Pelicand, J ; Phillip, M ; Limbert, C ; Danne, T ; Alonso, GT ; Rhodes, ET ; Davis, E ; Veeze, HJ ; Maahs, D ; Cardona-Hernandez, R ; Sumnik, Z ; Corathers, S ; Bratina, N ; Danne, T ; Gevers, E ; Imane, Z ; Piccini, B ; Forsander, G ; Pacaud, D ; Maffeis, C ; Campbell, F ; Bonfanti, R ; de Sanctis, L ; Krone, RE ; Toth-Heyn, P ; Witsch, M ; Arsanoglu, I ; Jefferies, C ; Landry, A ; Beltrand, J ; Amed, S ; Rami-Merhar, B ; Barat, P ; Szypowska, A ; Zabeen, B ; Casteels, K ; Savova, R ; Cherubini, V ; de Bock, M ; Todorovic, S ; Limbert, C ; Moravej, H ; Pozgaj Sepac, M ; Mazur, A ; Gerasimidou-Vazeou, A ; Iotova, V ; O’Riordan, S ; Chobot, A ; Herbst, A ; Ngwu, U ; Cody, D ; Birkebæk, NH ; Hanas, R ; Goksen, D ; Sarda, A ; Chobot, J ; Mirante, A ; Richmond Padilla, E ; Tsiroukidou, K ; Saboo, B ; Kanaka-Gantenbein, C ; Schiaffini, R ; Foskett, D ; Jali, S ; Verkauskiene, R ; Castro-Correia, C ; Kumar Guness, P ; Pelicand, J ; Cotterill, A ; Kumari Mohan, M ; Spehar Uroic, A ; Goss, P ; Svensson, J ; Ramchandani, GD ; Coutant, R ; Mantilla, L ; Sima, A ; Hyun Kim, J ; Galli-Tsinopoulou, A ; Ribeiro, R ; O’Gorman, C ; Fonna, H ; Bratke, H ; El Habashy, S ; Gokalani, R ; Scharf Pinto, M ; Chavda, V
Data: 2022
Identificador Persistente: http://hdl.handle.net/10400.17/4770
Origem: Repositório do Centro Hospitalar de Lisboa Central, EPE
Assunto(s): Adolescent; COVID-19; Child; Communicable Disease Control; Pandemics; Diabetes Mellitus, Type 1* / epidemiology; Glycated Hemoglobin; Registries; HDE END PED
Descrição
Objective: To analyze whether the coronavirus disease 2019 (COVID-19) pandemic increased the number of cases or impacted seasonality of new-onset type 1 diabetes (T1D) in large pediatric diabetes centers globally. Research design and methods: We analyzed data on 17,280 cases of T1D diagnosed during 2018-2021 from 92 worldwide centers participating in the SWEET registry using hierarchic linear regression models. Results: The average number of new-onset T1D cases per center adjusted for the total number of patients treated at the center per year and stratified by age-groups increased from 11.2 (95% CI 10.1-12.2) in 2018 to 21.7 (20.6-22.8) in 2021 for the youngest age-group, <6 years; from 13.1 (12.2-14.0) in 2018 to 26.7 (25.7-27.7) in 2021 for children ages 6 to <12 years; and from 12.2 (11.5-12.9) to 24.7 (24.0-25.5) for adolescents ages 12-18 years (all P < 0.001). These increases remained within the expected increase with the 95% CI of the regression line. However, in Europe and North America following the lockdown early in 2020, the typical seasonality of more cases during winter season was delayed, with a peak during the summer and autumn months. While the seasonal pattern in Europe returned to prepandemic times in 2021, this was not the case in North America. Compared with 2018-2019 (HbA1c 7.7%), higher average HbA1c levels (2020, 8.1%; 2021, 8.6%; P < 0.001) were present within the first year of T1D during the pandemic. Conclusions: The slope of the rise in pediatric new-onset T1D in SWEET centers remained unchanged during the COVID-19 pandemic, but a change in the seasonality at onset became apparent.
