Author(s):
Leal, Bárbara ; Chaves, João ; Carvalho, Cláudia ; Rangel, Rui ; Santos, Agostinho ; Bettencourt, Andreia ; Lopes, João ; Ramalheira, João ; Silva, Berta M. ; da Silva, António Martins ; Costa, Paulo P.
Date: 2017
Persistent ID: http://hdl.handle.net/10400.18/5430
Origin: Repositório Científico do Instituto Nacional de Saúde
Subject(s): Adult; Brain; Cytokines; Epilepsy, Temporal Lobe; Female; HLA-DR Antigens; Humans; Male; Microglia; Middle Aged; Toll-Like Receptor 4; Young Adult; Doenças Genéticas
Description
Neuroinflammation may be central in epileptogenesis. In this study we analysed inflammatory reaction markers in brain tissue of Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis (MTLE-HS) patients. TLR4, IL-1β and IL-10 gene expression as well as the presence of activated HLA-DR+ microglia was evaluated in 23 patients and 10 cadaveric controls. Inflammation characterized by the presence of HLA-DR+microglia and TLR4, IL-1β overexpression was evident in hippocampus and anterior temporal cortex of MTLE-HS patients. Anti-inflammatory IL-10 was also overexpressed in MTLE-HS patients. Our results show that hippocampal neuroinflammation extends beyond lesional limits, as far as the anterior temporal cortex.
